Manish Sharma, MD
2014 Alumni Scholars, Associate Junior Faculty Scholars
Dr. Sharma is a medical oncologist and clinical pharmacologist who focuses on the development of novel therapies for patients with all types of cancer, and gastrointestinal cancers in particular. His research involves computer-based modeling and simulation using data (including patient-reported outcomes) from oncology clinical trials. The broad objective of this research is to improve the development (by informing clinical trial design) and use of anticancer therapies. He has designed and conducted clinical trials that involve genotype-guided dosing of chemotherapy and repurposing of old drugs (such as sirolimus and metformin) as potential anticancer therapies. He is also using model-based phenotypes to develop genomic prediction tools for response to anticancer therapies. In an educational capacity, Dr. Sharma has an interest in improving doctor-patient communication with respect to informed consent for phase I cancer clinical trials.